AOL Web Search

  1. About 500,000,000 search results
  1. Web results:
  2. Nimodipine Floating Tablets Pdf more:



    It was found that nimodipine exists as mod I microcrystals in the solid dispersions and is stable for at least a three-month period. The tablets showed good floating properties and controlled release profiles, with drug release proceeding via the concomitant operation of swelling and erosion of the polymer matrix. Ajaykumar Patil et al/Int.J. PharmTech Res.2011,3(2) 621 Table 1: Composition of floating tablets of nimodipine and its inclusion complex with betacyclodextrin Ingredients (mg/tablet) Floating tablets formulated containing nimodipine alone gave very slow dissolution, whereas those formulated containing its inclusion complex with βCD gave slow, controlled and complete release . Studies on nimodipine sustained-release tablet capable of floating on gastric fluid with prolonged gastric resident time Hack instagram followers iphone. formulation of floating tablets, nimodipine was incorporated into poloxamer-188 solid dispersion after which it was directly compressed into floating tablets. It was observed that by increasing the HPMC and decreasing the PEG 6000 content, a decline in in vitro release of nimodipine occurred . The main drawback of such system is “all or tablets Nimodipine and spironolactone granules containing 10.0% of the drug, 1.0% . In order to prevent tablet floating, the dissolution test for spironolactone was conducted with apparatus 1 at 100 rpm and a different pharmacopoeia method (United States Pharmacopeia 2009), in 0.1 M hydrochloric acid . ifrpxncsfg.dns04.com. The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological . Do not disturb iphone alarms. The calibration curve of nimodipine for RP-HPLC method was linear over the range of 10–100 μg/mL. The retention time was found at 7.50 min for nimodipine. The variation for interday and intraday assay was found to be less than 0.72%. The proposed RP-HPLC was proved to be suitable for the determination of nimodipine in sustained release tablets. Prior to formulation of floating tablets, nimodipine was incorporated into polaxamer-188 solid dispersion after which it was directly compressed into floating tablets. It was observed that by increasing the HPMC and decreasing the PEG 6000 content a decline in in vitro release of nimodipine occurred. Codetaster normstahl bedienungsanleitung samsung. floating tablets were retained in stomach for 6 hours and further blood analysis studies showed that bioavailability of these tablets was 1.8 times that of the conventional tablets. Wu et al.,[37] developed floating sustained release tablets of nimodipine by using HPMC and PEG 6000. Prior to formulation of The calibration curve of nimodipine for RP-HPLC method was linear over the range of 10–100 μg/mL. The retention time was found at 7.50 min for nimodipine. The variation for interday and intraday assay was found to be less than 0.72%. The proposed RP-HPLC was proved to be suitable for the determination of nimodipine in sustained release tablets.

    International Journal of Pharmacy and Pharmaceutical Sciences

    Prior to formulation of floating tablets, nimodipine was incorporated into poloxamer‐188 solid dispersion after which it was directly compressed into floating tablets. It was observed that by increasing the HPMC and decreasing the PEG 6000 content, a decline in in vitro release of nimodipine The floating tablet formulations were evaluated for physical characterization, assay, swelling index, in‐vitro drug release, hardness, friability and weight variation.The results indicated that gas powered floating tablets of Itopride hydrochloride containing 125 mg HPMC K100M, 40 mg HPMC K15M, and 40 mg Carbopol provides a better option for ...

    Floating tablets of Nimodipine and its inclusion complex ...

    Ajaykumar Patil et al/Int.J. PharmTech Res.2011,3(2) 621 Table 1: Composition of floating tablets of nimodipine and its inclusion complex with betacyclodextrin Ingredients (mg/tablet) A novel sustained release gastric floating tablet containing solid dispersion withenhanced bioavailability and prolonged gastrointestinal resident time of the model drug nimodipine,apoorly soluble drug, was manufactured. Solid dispersion of nimodipine was prepared by a solventmelting method using poloxamer 188 as carrier. The floating tablet was made up of nimodipinepoloxamer 188 solid ... 557c - Free download as PDF File (.pdf), Text File (.txt) or read online for free. xc

    Floating tablets of Nimodipine and its inclusion complex ...

    Floating tablets formulated containing nimodipine alone gave very slow dissolution, whereas those formulated containing its inclusion complex with βCD gave slow, controlled and complete release ... tablets of 2 kg/cm2 hardness after immersion into the floating media floated immediately and tablets with hardness 4 kg/cm2 sank for 3 to 4 minutes and then came to the surface. Tablets in both cases remained floating for 24 hours. The tablet with 8 kg/cm2 hardness showed no floating capability. It was concluded that the buoyancy of the tablet ... Preparation and characterization of nimodipine-loaded nanostructured lipid systems for enhanced solubility and bioavailability Zaijin Teng,1,* Miao Yu,1,* Yang Ding,1,* Huaqing Zhang,1 Yan Shen,1 Menglao Jiang,1 Peixin Liu,1 Yaw Opoku-Damoah,2 Thomas J Webster,3 Jianping Zhou1 1Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing ...

    Floating Drug Delivery Systems: A Review

    Floating Drug Delivery Systems: A Review Vinay Kumar Katakam, Jagan Mohan Somagoni, Sunil Reddy, Chandra Mohan Eaga, Bala Ramesha Chary Rallabandi, Madhusudan Rao Yamsani* Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India Read "HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions, Carbohydrate Polymers" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

    Gastroretentive Floating and Mucoadhesive Drug Delivery ...

    nimodipine, theophylline Floating pellets Ofloxacin, tetracycline hydrochloride and theophylline, riboflavin Metronidazole , lansoprazole Floating Capsules Nicardipine hydrochloride, verapamil Ofloxacin, propranolol hydrochloride, L-dopa and benserazide 2.1.3 Role of Polymers in Floating drug delivery Floating Review - Free download as PDF File (.pdf), Text File (.txt) or read online for free. review article on FDDS. review article on FDDS. Buscar Buscar. Fechar sugestões. Enviar. pt Change Language Mudar idioma. Entrar. Assinar. Saiba mais sobre a Assinatura do Scribd. Best-sellers. Livros. Audiolivros. Snapshots. Revistas.

    Development and Validation of a RP-HPLC Method for ...

    The calibration curve of nimodipine for RP-HPLC method was linear over the range of 10–100 μg/mL. The retention time was found at 7.50 min for nimodipine. The variation for interday and intraday assay was found to be less than 0.72%. The proposed RP-HPLC was proved to be suitable for the determination of nimodipine in sustained release tablets. nimodipine floating tablet formulation and optimization by artificial neural networks and genetic programming. European Journal of Pharmaceutics and Biopharmaceutics 77, 122–131. Perepelkin KE. (2005), Polymeric materials of the future based on renewable plant resources and biotechnologies. Fibre Chemistry 37: 417-430.

    Development and Validation of a RP-HPLC Method for ...

    Content of Nimodipine in Sustained Release Tablets. Nimodipine was determined with the proposed method. The results of the assay yielded 99.28 ± 0.34% for nimodipine, thus showing that the method was selective and accurate for the determination of nimodipine without interference from the excipients in the sustained release tablets dosage form. The sustained release tablets can be expected to reduce the frequency of administration and decrease the dose dependent side effects associated with repeated administration of conventional Aceclofenac[14]. Sagar Balaso Sangale conducted a study on Formulation and evaluation of floating Felodipine microsphere.

    REVIEW OF LITERATURE

    Prior to formulation of floating tablets, nimodipine was incorporated into polaxamer-188 solid dispersion after which it was directly compressed into floating tablets. It was observed that by increasing the HPMC and decreasing the PEG 6000 content a decline in in vitro release of nimodipine occurred. The particular aim of the present study was to investigate the mechanism, kinetics, and factors affecting the polymorphic transformation of nimodipine (NMD) and indomethacin (IMC) during the high shear wet granulation process; the effects of independent process variables including impeller speed and granulating temperature will be taken into ...

    Solid dispersions in the development of a nimodipine ...

    It was found that nimodipine exists as mod I microcrystals in the solid dispersions and is stable for at least a three-month period. The tablets showed good floating properties and controlled release profiles, with drug release proceeding via the concomitant operation of swelling and erosion of the polymer matrix. These tablets were prepared by direct compression method using various bioadhesive polymers like HPMC K4M, HPMC K100M.The formulated gastro retentive floating tablets were evaluated for different parameters such as drug excipient compatability studies, weight variation, thickness, hardness, content uniformity, Invitro Buoyancy studies , In ... In this study, fluid bed granulation was applied to improve the dissolution of nimodipine and spironolactone, two very poorly water-soluble drugs. Granules were obtained with different amounts of sodium dodecyl sulfate and croscarmellose sodium and then compressed into tablets.

    (PDF) Studies on nimodipine sustained-release tablet ...

    Studies on nimodipine sustained-release tablet capable of floating on gastric fluid with prolonged gastric resident time Formulation and Evaluation of Floating Matrix Tablets of Telmisartan - Free download as PDF File (.pdf), Text File (.txt) or read online for free. Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. 全部 DOC PPT TXT PDF XLS. ... Prior to formulation of floating tablets, nimodipine was incorporated into poloxamer-188 solid dispersion after which it was directly compressed into floating tablets. It was observed that by increasing the HPMC and decreasing the PEG 6000 content a decline in in vitro release of nimodipine occurred. Wong et al60 ...

    Preparation and in vitro characterization of non ...

    This drug has a narrow absorption window in the upper gastrointestinal tract and it would benefit from a gastroretentive delivery system. Floating drug delivery system (FDDS) is a gastroretentive system that can be effervescent or non-effervescent. Wu et al. (3) prepared floating sustained release tablets of nimodipine using HPMC and PEG 6000. Table 2 Buoyancy of formulated ranitidine hydrochloride floating tablets. Gastric retention is influenced by many factors such as gastric talc, magnesium stearate. Thus with this system a pulsatile drug delivery system can be prepared to increase the therapeutic effectiveness of the drug.

    Formulation and evaluation of a gastroretentive dosage ...

    The tablets were evaluated for in vitro drug release, floating time, floating lag time, swelling studies etc. The tablets formulated with HPMC K4M CR and HPMC K15M CR along with Poloxamer showed negligible floating lag time with a total floating time over 12 hrs with complete release. nimodipine and impurities in tablets using experimental design methodology”. Journal of Pharmaceutical and Biomedical Analysis, 49 (2009) 1192-1202. 2. ... development of nimodipine effervescent floating tablet formulations and optimization by genetic programming”. European Journal of Pharmaceutics and Biopharmaceutics,

    Polymers for Floating Drug Delivery System

    floating tablets were retained in stomach for 6 hours and further blood analysis studies showed that bioavailability of these tablets was 1.8 times that of the conventional tablets. Wu et al.,[37] developed floating sustained release tablets of nimodipine by using HPMC and PEG 6000. Prior to formulation of Floating Tablets_final With Correction - Free download as Word Doc (.doc), PDF File (.pdf), Text File (.txt) or read online for free. Scribd es red social de lectura y publicación más importante del mundo. Buscar Buscar. Cerrar sugerencias. Cargar. es Change Language Cambiar idioma.

    Preparation and in vitro characterization of non ...

    Non-effervescent floating tablets were prepared with a combination of optimized solid dispersions and release retarding polymers/swellable polymers such as xanthan gum and polyethylene oxide. Tablets were evaluated for physicochemical properties such as hardness, thickness and buoyancy. The aim of the present study was to develop sustained release formulation of Verapamil Hydrochloride to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of HPMC polymers, Guar gum, and Xanthum gum were employed as polymers. Verapamil Hydrochloride dose was fixed as 120 mg. Total weight of the tablet was considered as 400 mg. Polymers were used in the ...

    (PDF) FORMULATION AND EVALUATION ASPECTS OF TABLETS-AN ...

    FORMULATION AND EVALUATION ASPECTS OF TABLETS-AN OVERVIEW Formulation, Development of Sustained release Tablets of NIMODIPINE and its Bio-statistical Optimization. Bhawna Khurana Jaipur College of Pharmacy, Jaipur, Rajasthan

    Floating drug delivery systems: A review

    The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological ... The purpose of writing this review on floating drug delivery systems ... Ma GD, Fu CD. Studies on nimodipine sustained release tablet capable of floating on gastric fluids with prolonged gastric resident time.Yao Xue Xue ... Stability studies of ampicillin floating tablets (Ampiflot) and buffered Ampiflot [master's thesis]. 1987, Jamaica, NY ... Read "Assessing the impact of nimodipine devitrification in the ternary cosolvent system through quality by design approach, International Journal of Pharmaceutics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

    FLOATING DRUG DELIVERY SYSTEM - A NEW ERA IN NOVEL DRUG ...

    formulation of floating tablets, nimodipine was incorporated into poloxamer-188 solid dispersion after which it was directly compressed into floating tablets. It was observed that by increasing the HPMC and decreasing the PEG 6000 content, a decline in in vitro release of nimodipine occurred . The main drawback of such system is “all or 1: ZHAO Li-hua,ZOU Ruo-fei,XU Xue-jun(Medicine BuUetin of Anhui Provincid Corps Hospital,The Chinese People's Armed Police Force,Hefei Anhui 230041);Determin ation of gliclazide sustained-release tablets by ultraviolet spectrophotometry[J];Anhui Medical and Pharmaceutical Journal;2007-05 2 CHAPTER-2 LITERATURE REVIEW Literature survey R. N. Sonpal et al (2011) discussed the fundamental idea of solid dispersion, ... They developed floating tablets for sustained release of drug comprising poly-propylene foam-powder, matrix ... of dissolution of Nimodipine. The dissolution of Nimodipine SDs as compare to .

    Using Fluid Bed Granulation to Improve the Dissolution of ...

    tablets Nimodipine and spironolactone granules containing 10.0% of the drug, 1.0% ... In order to prevent tablet floating, the dissolution test for spironolactone was conducted with apparatus 1 at 100 rpm and a different pharmacopoeia method (United States Pharmacopeia 2009), in 0.1 M hydrochloric acid ... The present invention relates to an osmotic floating tablet comprising: (i) an inner core comprising a drug, one or more low density polymers, and one or more pharmaceutically acceptable excipients; and (ii) an outer osmotic coating surrounding the inner core that is substantially permeable to surrounding fluids and substantially impermeable to the drug. 2003 First report osmotic floating system (Mishra etal, 2006) ... core tablets by using modified punches having needle on upper punch. This indentation is not covered during coating process which acts as a path for drug release in osmotic system. 4. Use of leachable substances in the

    Journal of Chemistry - Hindawi Publishing Corporation

    The calibration curve of nimodipine for RP-HPLC method was linear over the range of 10–100 μg/mL. The retention time was found at 7.50 min for nimodipine. The variation for interday and intraday assay was found to be less than 0.72%. The proposed RP-HPLC was proved to be suitable for the determination of nimodipine in sustained release tablets. Presently, various approaches have been exploited in the prolongation of gastric residence time which includes floating drug delivery system (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems and high density ... pdf. A Review on Emerging Floating Drug Delivery System. D. Swamiappan. Download with Google ...

    Floating Drug Delivery Systems: A Review

    a. Single Layer Floating Tablets: They are formulated by intimate mixing of drug with a gel-forming hydrocolloid, which swells in contact with gastric fluid and maintains bulk density of less than unity. They are formulated by intimate mixing of drug with low-density enteric materials such as HPMC. b. Bi-layer Floating Tablets: A bi-layer manner that was amenable to modification by the process variables Floating from PHARMACOLO 201 at Acharya Institute of Technology